Patients with GI Cancer
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ePORE^® therapy with EndoVE^® can be used for the treatment of gastrointestinal cancers including oesophageal, colorectal, gastric and rectal cancer.

Yes, ePORE^® therapy delivers high frequency pulsed electrical fields which can be administered to GI cancers directly with the EndoVE^® device. A procedure may be carried out under light sedation or under certain circumstances may require general anaesthesia and this will be determined by the clinical team.

Patients are usually treated as a day case, however, this must be assessed on a patient-by-patient basis and in some cases, it may be more appropriate to keep the patient under surveillance for the night after the operation.

Some patients may experience a mild fever following the treatment, but pain-relieving medication can be prescribed to relieve this.

 Serious side effects are extremely rare and will be explained by the clinical team responsible for your care.

This is determined by the stage of the disease and how far advanced it is at the time of treatment. Typically early stage disease is managed with local surgery with more advanced disease treated using a combination of surgery, chemotherapy and radiotherapy. 

ePORE^® therapy delivered with EndoVE^® is currently utilised for later stage disease in patients considered unsuitable for surgery with the goal of controlling symptoms and improving patient’s overall quality of life.

Research and clinical studies in managing GI cancers with EndoVE^® in combination with calcium are ongoing in earlier stage disease.

ePORE^® therapy aids in stopping or reducing bleeding caused by GI cancers by immediately inducing vasoconstriction of the capillaries supplying blood flow to the tumour. Additionally, ePORE^® therapy results in long-term disruption of the cytoskeletal structure of the tumour cells, and also causes the barrier function of the microvascular endothelium to be compromised. Tumour cells are consequently exposed to a lack of oxygen and nutrients due to the disruption in blood flow to the tumour and facilitates inducing their  death.

ePORE^® therapy is a localised precision treatment and is typically delivered alone. The clinical team will consider all the available suitable options for care and will advise on the best approach to take. 

If a patient has a pacemaker, then treatment should not be delivered in areas that are in close proximity to the pacemaker. Please advise the clinical team if you have a pacemaker and require treatment with ePORE^® 

Very low concentrations of bleomycin are used and maintain their effectiveness due to the increased porosity of the tumour cells, thereby allowing maximum absorption of a low dose chemotherapeutic drug. If bleomycin is injected intravenously, the dose provided is 15,000 IU/m2. If injected intratumorally,  it is delivered at a concentration of 1000 IU/ml with the total dosage determined by the volume of the tumour. Please refer to the reference section for further information.

Very few side effects associated with the use of bleomycin in combination with pulsed electrical fields have been observed  as the doses used are significantly lower than the standard doses deployed during conventional chemotherapy treatment. Please refer to the reference section for further information.

The published evidence demonstrates that pulsed electrical fields, tissue electroporation, is effective in a wide range of solid tumour histology subtypes.  Typically, bleomycin when delivered alone is used in only a small number of cancer types however when administered in combination with pulsed electrical fields its effectiveness is greatly expanded. Bleomycin works by binding with DNA and breaking its structure which forces the cell into a cell death pathway. Very few molecules of bleomycin are required to trigger cell death however normally its ability to enter a cell is limited due to the large size of the bleomycin molecule and its inability to cross the cell membrane.  ePORE^® therapy overcomes this barrier and enables highly effective localised tumour cell death without toxicity to healthy tissue structures. Please refer to the reference section for further information.